Archive for April, 2010
Hyaluronic Acid is one of the main components of Youthful skin, along with Organic Silica; it becomes vastly depleted with Age. This video shows how one Japanese village has numerous people living well into their 90’s without significant wrinkles. Although, I would not call them young, they do have youthful attributes despite the fact that many of them smoke.
What is interesting here is that the mechanism of Ageing is more like a program triggering the catabolism of the body rather than a general deterioration. It turns out that the protein Sirt6 regulates telomerase production which determines the lenght of the telomeres. The protein also inhibits the production of another protein called NF Beta Kappa B which actively breaks body tissue down. SIRT6 is a cousin of SIRT1 which is also known to have anti-aging effects. SIRT1 is found naturally in Resveratrol in Grapes and Knot weed.
By Richard Alleyne
Researchers have found two connected chemical triggers that regulate the lifespan of cells and believe that, by influencing them, they can increase longevity and reduce the signs of ageing.
The study by Stanford University in California builds on the growing belief that age-related degeneration of tissues, organs and even facial skin, is an active, deliberate process by the body rather than a gradual failure of tired cells.
The team has found two proteins that seem to directly affect ageing. One – known as SIRT6 – which protects against cell ageing and another – known as NF Kappa B – which promotes it.
What is even more exciting is that the study has discovered for the first time that the two substances influence each other – and that manipulating their relative availability in the body could add years to the average life and reduce wrinkles…..
The scientists concluded that SIRT6 and NF Kappa B may work together to help cells age appropriately as the former “puts the brakes” on the latter. “It seems that an important job of SIRT6 is to restrain NF Kappa B and limit the expression of genes associated with ageing,” said Dr Chang.
Cont’ @ Source
Again we have evidence that the telomeres determine the age of the body. If systemically, we can reverse telomere shortening, then we have a real visible age reversal effect.
By Richard Alleyne, Science Correspondent
Researchers have found that drinking damages part of the cells that are linked to premature ageing and cancer. They discovered that it causes stress and inflammation to telomeres – the ends of DNA strands that stop them unravelling much like the ends of shoelaces. As people age, telomere length shortens progressively and eventually they are so damaged the cell dies.
The study found alcohol accelerates this process. Since telomere shortening is thought to also increase cancer risk, the researchers speculated that those with shorter telomeres due to heavy alcohol consumption would have an increased risk of cancer.
Cont’ @ Source
RNA Regenerator– increases production of telomerase to reverse telomere deterioration.
ScienceDaily (Sep. 28, 2009) — Never mind facial masks and exfoliating scrubs, skin takes care of itself. Stem cells located within the skin actively generate differentiating cells that can ultimately form either the body surface or the hairs that emanate from it. In addition, these stem cells are able to replenish themselves, continually rejuvenating skin and hair. Now, researchers at Rockefeller University have identified two proteins that enable these skin stem cells to undertake this continuous process of self-renewal.
RNA Regenerator– Activates an increase in telomerase.
The work, published in Nature Genetics, brings new details to the understanding of how stem cells maintain — and lose — their status as stem cells and are able to specialize into various types of cells. It also further dissects a ubiquitous Rube Goldberg-like pathway whose molecular gears and levers play an important role in activating stem cells to divide and transform into tissue-making cells.
Lead researcher Elaine Fuchs, head of the Laboratory of Mammalian Cell Biology and Development, and first author Hoang Nguyen, a former postdoc in the lab, worked with mice engineered to lack the proteins TCF3 and TCF4, which reside in the nucleus of skin stem cells, where they bind to DNA to turn genes off that would otherwise cause the stem cells to differentiate. They found that without TCF3 and TCF4, all of the layers of the mice’s skin still develop properly, but they cannot be maintained.
Silver generates pluripotent stem cells.
“The epidermal stem cells — one of the types of stem cells in the skin — lose their capacity to self-renew and replace skin cells that have died,” says Nguyen, who is now an assistant